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Serenity Prime Skullcap: The American Herb in the Blend
Skullcap is one of the quieter names on the Serenity Prime list. It is a calming herb from North America, and in 2025 it got its own sleep study.
The skullcap in Serenity Prime is Scutellaria lateriflora, known as American skullcap. A 2025 study gave 400 mg a day for 56 days to people with mild to moderate sleep trouble and measured sleep quality. A separate two-week calm study used 350 mg three times daily. The bottle does not print its skullcap amount, so follow the label on your bottle.
Key facts
- Serenity Prime skullcap is Scutellaria lateriflora, the American species.
- The research uses the aerial parts of the plant.
- A 2025 sleep study used 400 mg a day for 56 days and measured sleep-quality scores.
- A two-week calm study in healthy volunteers used 350 mg three times daily.
- Chinese skullcap, Scutellaria baicalensis, is a different plant with its own research.
- Drowsiness is the effect reported, which suits a night-time capsule.
What is the skullcap in Serenity Prime?
Skullcap is a small flowering herb in the mint family. The species in sleep and calm research is Scutellaria lateriflora, often called American skullcap. The research uses its aerial parts, the leaves, stems and flowers that grow above the ground.
Serenity Prime lists it with one word: Skullcap. It is one of the 13 names on the formula, next to calming herbs like chamomile, passiflora, lemon balm and hops. You can see the full list on the Serenity Prime ingredients page.
Skullcap is also one of the seven names that were never drawn for the pack artwork. The others are calcium, vitamin B6, magnesium, melatonin, L-taurine and ashwagandha. So the pictures on the box are not a guide to what matters most in the formula.
American skullcap or Chinese skullcap?
This is the most useful thing to know about skullcap. Two different plants share the name. American skullcap is Scutellaria lateriflora. Chinese skullcap is Scutellaria baicalensis.
Chinese skullcap is a common and reasonable supplement ingredient with its own separate research. But it is not the plant used in the skullcap sleep and calm studies. Both trials in the skullcap research used Scutellaria lateriflora, the American species.
A one-word ingredient name covers both plants. When you compare any calm or sleep product that lists skullcap, the Latin name tells you which herb you are getting.
What does the skullcap research show?
American skullcap has two human trials. Here is what each one used. These are the study doses, not the amounts in a Serenity Prime capsule.
| Study | Dose used | What was measured |
|---|---|---|
| 2025 sleep study | 400 mg a day for 56 days | Sleep-quality scores in mild to moderate sleep trouble |
| Calm study | 350 mg three times daily | Calm scores over two weeks, in healthy volunteers who were not anxious to start with |
Doses as the studies used them. Not amounts in this capsule.
The 2025 study is the one that matters most for Serenity Prime. It was a sleep study, it ran for 56 days, and sleep quality was the main outcome. That is close to the eight-week window most people use to judge a sleep supplement.
The calm study is useful background. It ran for two weeks in healthy volunteers who were not anxious to start with. Together, the two studies give skullcap a place among the six Serenity Prime ingredients that have been given to people with a sleep outcome.
Skullcap plus 12 more names
One bottle is $69, three are $177 and six are $294. Every pack ships free in the US with a 60-day money-back guarantee.
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How does skullcap fit with the rest of the formula?
Serenity Prime mixes three kinds of ingredients. Melatonin speaks to the body clock. Minerals such as magnesium and calcium support normal daily needs. Calming herbs, skullcap among them, round out the evening wind-down.
Skullcap's study ran daily for 56 days without a set hour. So there is no timing rule for skullcap on its own. That makes it easy to take with the rest of the capsule in the evening.
For a wider view of how the 13 names work together, read how Serenity Prime works. For the full evidence ranking, see which ingredients have sleep research.
How to take Serenity Prime for the skullcap
Take the capsule about an hour before bed, at the same time each night, with water. Food is optional. That routine comes from our how to use page, and it suits every herb in the blend.
A bottle holds 60 capsules and is sold as a 30-day supply. The serving printed on your bottle is the one to follow. If your label is unclear, customer support on +1 (302) 200-3480 can confirm it.
Plan for eight weeks. The skullcap sleep study ran 56 days, and buyers most often report a wait of 4 to 8 weeks. A three-bottle pack covers 90 days, which is longer than that study ran.
Is skullcap safe in Serenity Prime?
On our side effects page, skullcap sits with passiflora, hops, lemon balm and L-taurine. Drowsiness is the effect reported for that group, which is the intended one at night. No interaction of note is established at ordinary amounts.
The full formula also holds St. John's wort and ashwagandha, so anyone on a prescription medicine, or with a liver condition, should show the ingredient list to a doctor first. Anyone under 18, pregnant or nursing should ask before starting.
Frequently asked questions
Which skullcap is in Serenity Prime?
Skullcap is listed as one of the 13 ingredients. The skullcap sleep and calm research uses Scutellaria lateriflora, American skullcap, which is a different plant from Chinese skullcap.
How much skullcap did the sleep study use?
The 2025 sleep study used 400 mg a day for 56 days. That is the study dose, not the amount in a Serenity Prime capsule, which the bottle does not print.
Does skullcap cause side effects?
Drowsiness is the effect reported, which suits a night-time capsule. No interaction of note is established at ordinary amounts. Ask your doctor first if you take prescription medicine.
Serenity Prime® is a dietary supplement, not a drug. These statements have not been evaluated by the Food and Drug Administration. It is not a medicine and is not meant for any medical condition. Take medical questions to your doctor or pharmacist.
Give it the full 56 days
A three-bottle pack covers 90 days at $59 a bottle, and the 60-day guarantee covers opened bottles.
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