Serenity Prime Ingredients

Label order tells you what the seller wants read first. Sorted by how much human evidence stands behind each name, the same thirteen fall into six groups, and the distance between the top and the bottom of the list is larger than the bottle suggests.

Classed by this desk from the trials cited further down this page. The class describes the published research on the ingredient, never the capsule.

Two names carry real trial weight. Ashwagandha has a ten-week study in people whose sleep was measured rather than remembered, and melatonin has more human data than the other twelve put together.

The last three rows are the interesting ones, and each is interesting for a different reason: hops has always been studied with another herb beside it, St. John’s wort has been studied heavily for something else entirely, and taurine has no sleep trial in people at all.

This is the single question worth asking of any nighttime blend, and it separates the thirteen into three piles rather than two.

Every row is a statement about the published literature. None of it is a statement about what this capsule does.

Six of the thirteen have been given to people with a sleep outcome as the point of the study, which is a better hit rate than a lot of shelf blends manage. Three more are adjacent: something related to sleep or stress was measured, but nobody set out to treat insomnia with them.

The remaining four are there on reasoning rather than on results. A formulator can defend each choice, and none of the four is inert or unsafe at ordinary amounts. They are simply not what the sleep case rests on.

For a botanical, the plant part changes the ingredient. Root and leaf from one species are two different raw materials with two different chemistries, and the trials almost never cover both. Here is what the published naming looks like against what the seller’s list gives.

The right-hand column is the whole of the seller’s naming. A part, a species and an extract ratio would each change what the left-hand column can be read across to.

Skullcap is the clearest case. Both trials in the literature used Scutellaria lateriflora, the American species. A different skullcap, Scutellaria baicalensis, is a common and entirely reasonable supplement ingredient with its own separate research. A one-word ingredient name covers both.

St. John’s wort is the one where the missing figure has a safety edge to it. A 2020 review of its interactions shows that the enzyme induction responsible for them tracks hyperforin content, so a hyperforin figure is the number that tells a reader how much interaction risk a preparation carries.

Passiflora is the one where the industry itself has been surveyed: a 2025 comparison of food supplements against registered herbal medicines found the two categories are not interchangeable on content.

The vendor drew six of the thirteen. Those six appear as tall cut-outs and again in the line-up strip the seller uses on its own page, so they are the names a browsing buyer sees most often.

Seven of the thirteen were never drawn at all: calcium, vitamin B6, magnesium, melatonin, L-taurine, skullcap and ashwagandha. Four of those are the ones with the strongest human sleep evidence in the whole formula, which makes the illustration set a poor guide to the formula’s substance.

That is an ordinary marketing decision rather than a fault. Botanicals photograph well and a white mineral powder does not. It is worth knowing about only because the strip reads like an ingredient list and is not one.

The single graphic that comes closest to a list is the seller’s “inside” panel, and it names six: Calcium, Vitamin B6, Magnesium, Melatonin, Goji, Chamomile. The line-up strip names a different six. Neither reaches thirteen, so the seller’s written list is the one to work from.

A thirteen-ingredient capsule is not thirteen trials added up. Combination effects can run either way, and the honest answer for this formula is short.

• Magnesium and vitamin B6 are the one pair in this bottle that has been given to people together. A randomised trial in restless legs syndrome ran 40 mg of B6 a day against 250 mg of magnesium oxide a day in 75 patients. It is a different condition from insomnia, and it is still the closest thing to a combination result the list contains.
• Hops and valerian is the pairing the hops evidence belongs to, and valerian is not one of the thirteen. The fixed-combination trial and the multicentre trial against diphenhydramine both tested the pair as one preparation.
• Lemon balm and valerian is the same shape of problem. The best-known lemon balm anxiolytic result comes from a combination study, which is why this page cites the single-herb crossover for lemon balm instead.
• Ashwagandha and melatonin have been run head to head and also in combination. A 2026 trial compared ashwagandha root extract, melatonin, both together and placebo over eight weeks, which makes it the most directly relevant combination study to any capsule carrying both.
• The other nine have no combination data with anything else on this list. Nobody has swallowed all thirteen together in a trial, and no formula of this size in this category has.

None of that argues against blends. It argues for reading a blend as a formulation decision rather than as a stack of thirteen separate results, and for treating the sixty-day window as the place where the question gets settled for one person.

This is the section that says the awkward thing once, so that the rest of the page does not have to keep hinting at it.

The seller names thirteen ingredients and no amount is published for any of them. There is no Supplement Facts panel on the bottle front, none in the vendor’s twenty-one-file image pack, and none on the seller’s own page. The back of the bottle has never been photographed, so serving size, servings per container and every %DV are unknown to this desk and to the buyer.

What follows from that is specific rather than general. Four consequences, and no more than four:

• Melatonin becomes unreadable. The trial that ran three strengths side by side settled on a few tenths of a milligram, and ten times that added nothing. Thirty-fold differences in melatonin content are ordinary in this market: an assay of thirty-one products found label content between 83 per cent below and 478 per cent above the stated figure. Without a figure there is nothing to be sceptical about.
• Two upper intake levels cannot be checked. The Institute of Medicine sets the supplemental magnesium upper intake at 350 mg a day and the B6 upper intake at 100 mg a day for adults. A blend of this kind is very unlikely to approach either, and a reader who wants to confirm that cannot.
• The St. John’s wort cannot be sized. Its interaction profile scales with hyperforin, and a capsule carrying a trace is a different proposition from one carrying a clinical dose. Both are consistent with the label.
• The trial doses stay one-sided. Every milligram figure on this website belongs to a published study. Not one of them is an amount in this capsule, and nothing here should be read as implying otherwise.

Naming what is absent from a list is as useful as naming what is on it, especially for anyone comparing two bottles on a shelf.

• No valerian. The most-studied herb in this whole category is not among the thirteen. That matters specifically for the hops row, whose human evidence is valerian-combination evidence.
• No 5-HTP, no GABA, no L-theanine and no glycine. The four amino-acid-style ingredients that usually turn up in nighttime blends are all absent from the list.
• No antihistamine. This is a dietary supplement, not a sleep medicine. Diphenhydramine and doxylamine, the actives in over-the-counter sleep aids, are drugs and belong to a different aisle.
• No caffeine and no stimulant. Nothing on the list is a stimulant, which is worth confirming for an evening capsule.
• Nothing on the list is a controlled substance, and nothing on it is prescription-only in the United States.

One caveat belongs with that list, and it belongs here rather than scattered: the thirteen are the ingredients the seller names, and the capsule shell, any flow agent and any filler come from the same unpublished back label. Anyone avoiding gelatin, a specific dye or a common allergen should ask the order desk before ordering rather than assume from the front of the bottle.